Renal Cell Cancer
Elevated Blood Pressure And High Bmi Increase Risk Of Renal-Cell Cancer - Brief Article Kidney cancers make up 2% to 3% of new cases of cancer in the US each year. Renal-cell carcinoma is one of the most rapidly increasing forms of tumors in incidence. However, renal-pelvis cancers have declined over the past 20 years. There is conflicting research regarding the association of obesity and hypertension to kidney cancers.
To better understand these affiliations, researchers conducted a study of newly diagnosed kidney cancer during a follow-up period of 25 years. In doing so, they looked at the health records of 363,992 Swedish men from 1971 to 1992 until death at the end of 1995. The subjects who were diagnosed with kidney cancer were discovered through the use of information from the population-based Swedish Cancer Registry. Measurements of height, weight, and blood pressure were obtained at an initial examination. Poisson regression analysis was employed to estimate relative risks, using adjustments for age, smoking status, body-mass index (BMI), and diastolic blood pressure.
When compared with the subjects in the lowest three-eighths of the cohort for BMI, men in the middle three-eighths were found to have a 30% to 60% increased risk of renal-cell cancer, while men in the highest two-eighths had close to double the risk. A direct association between higher blood pressures and a higher risk of renal-cell cancer was also seen. These results were consistent throughout the followup period. There was no association between BMI or blood pressure and the risk of renal-pelvis cancer.
This research indicates that both a higher BMI and elevated blood pressure independently increase the risk of developing renal-cell cancers in men. Efforts should be made to both decrease weight and control blood pressure in men to reduce their risk of developing renal-cell cancer.
S. Cholw, G. Grindley, J. Fraumeni, et al., Obesity, Hypertension, and the Risk of Kidney Cancer in Men. N Engl J Med;343:1305-1311 (November 2, 2000) [Correspondence: Dr. Chow, National Cancer Institute, 6120 Executive Blvd., EPS 8100, Bethesda, MD 20892-7240. E-mail: choww@mail.nih.gov.]
COPYRIGHT 2000 Technical Insights, a divison of John Wiley & Sons.
COPYRIGHT 2001 Gale Group
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