Epo Drug
Glycoform characterization of intact proteins by mass spectrometry: erythropoietin (EPO).(Biological)(Advertisement)Pelzing, Matthias; Neususs, Christian; Demelbauer, Uwe The separation and mass characterization of isomeric glycoforms of intact proteins by capillary electrophoresis-electrospray time-of-flight mass spectrometry is shown for erythropoietin. About 135 isoforms of human erythropoietin could be distinguished, demonstrating the promising applicability for therapeutic drug development of glycoproteins.
Glycosylation strongly influences the functionality of proteins, showing a broad distribution of isoforms, depending on species and environment. EPO plays a key role in the production of red blood cells and is currently one of the most ...
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